| 20/09/2018 |
| AEK Larnaca - Zurich | 0-1 |
| Ludogorets - Leverkusen | 2-3 |
| Leipzig - RB Salzbourg | 2-3 |
| Celtic Glasgow - Rosenborg | 1-0 |
| Copenhague - Zenit Saint-Pétersbourg | 1-1 |
| Slavia Prague - Bordeaux | 1-0 |
| Spartak Trnava - Anderlecht | 1-0 |
| Dinamo Zagreb - Fenerbahce | 4-1 |
| Sporting Portugal - Qarabag | 2-0 |
| Arsenal - Vorskla | 4-2 |
| F91 Dudelange - Milan | 0-1 |
| Olympiakos - Betis Séville | 0-0 |
| Villarreal - Glasgow Rangers | 2-2 |
| Rapid Vienne - Spartak Moscou | 2-0 |
| Marseille - Francfort | 1-2 |
| Lazio - Apollon Limassol | 2-1 |
| Genk - Malmö | 2-0 |
| Besiktas - Sarpsborg 08 | 3-1 |
| Akhisar - Krasnodar | 0-1 |
| Séville - Standard | 5-1 |
| Rennes - Jablonec | 2-1 |
| Dynamo Kiev - Astana | 2-2 |
| PAOK Salonique - Chelsea | 0-1 |
| Videoton - Bate Borisov | 0-2 |
